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Upon clinical suspicion of SM, a complete workup is recommended, often beginning with serum tryptase1,2
Serum tryptase testing is recommended as an initial step in evaluating the diagnosis of SM1,2
Tryptase is a serine protease stored and released by mast cells. Elevated tryptase levels serve as a highly specific marker of mast cell activation.3
Serum tryptase >20 ng/mL is one of the WHO minor criteria for SM4
Download the tryptase test pocket card
Consider referring patients for a bone marrow examination if you record:1
- Typical skin lesions
- Spontaneous anaphylaxis
- Persistently elevated tryptase levels
- REMA score (high risk = ≥2 points)
REMA=Red Española de Mastocitosis (Spanish Network on Mastocytosis).
Review case studies
Learn when and how to perform testing if SM is suspected
References V
Valent P, et al. J Allergy Clin Immunol Pract. 2022;10(8):1999–2012.e6.
Theoharides TC, et al. N Engl J Med. 2015;373(2):163–172.
Valent P, et al. Expert Rev Hematol. 2014;7(5):683–690.
Valent P, et al. Hemasphere. 2021;5(11):e646.
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