Every patient has a story of symptoms, could it be systemic mastocytosis?

Every patient has a story of symptoms, could it be systemic mastocytosis?

Drawing of an middle-aged woman experiencing different symptoms related to systemic mastocytosis

Recognising common symptoms is just the beginning. Systemic mastocytosis (SM) can present in patients as a range of unpredictable and debilitating symptoms across multiple organ systems—from skin lesions, anaphylaxis and diarrhoea, to organ damage1

Early diagnosis of disease and active management of life-threatening symptoms, such as anaphylaxis, are critical2,3


What is anaphylaxis?

Anaphylaxis, a result of mast cell mediator release, is an acute and suddenly occurring systemic hypersensitivity reaction in multiple organ systems. In severe episodes, patients may experience palpitations, dizziness and reduced blood pressure due to vasodilation4,5

Ask these questions to help lead you to SM

What is SM and how can it impact my patients?


How can I investigate
an SM diagnosis?


References V

  1. Jennings SV, et al. Immunol Allergy Clin North Am. 2018;38(3):505–525.
  2. Shomali W, Gotlib J. Hematology. 2018;2018(1):127–136.
  3. Jensen B, et al. J Clin Nurs. 2019;28(7–8):1114–1124.
  4. Gülen T, et al. Clin Exp Allergy. 2014;44(1):121–129.
  5. Gülen T, et al. J Intern Med. 2016;279(3):211–228.

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